574625 Suramin, Sodium Salt - CAS 129-46-4 - Calbiochem

574625
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₅₁H₃₄N₆O₂₃S₆ . 6Na 129-46-4

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      574625-50MG
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          Plastic ampoule 50 mg
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          Description
          OverviewA reversible and competitive inhibitor of protein tyrosine phosphatases. An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. Inhibits GDP-GTP exchange, the rate limiting step in the activation of Gα-subunits. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerases I and II. Inhibits Ca2+-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors, including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC50 = 15 µM). Reported to interact with ATP-binding enzymes and P2-purinergic receptors. An effective inhibitor of angiogenesis in the calmodulin assay when given in combination with angiostatic steroids.
          Catalogue Number574625
          Brand Family Calbiochem®
          SynonymsPTP Inhibitor VI, Purinergic Receptor P2Y Antagonist I, P2Y Antagonist I
          References
          ReferencesMeyers, M.O., et al. 2000. J. Surg. Res. 91, 130.
          Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
          Waldhoer, M., et al. 1998. Mol. Pharmacol. 53, 808.
          Zhang, Y.L., et al. 1998. J. Biol. Chem. 273, 12281.
          Hohenegger, M., et al. 1996. Mol. Pharmacol. 50, 1443.
          Emmick, J.J., et al. 1994. J. Pharmacol. Exp. Ther. 269, 717.
          Denhertog, A., et al. 1992. J. Physiol. 454, 591.
          Nakajima, M., et al. 1991. J. Biol. Chem. 266, 9661.
          Wilks, J.W., et al. 1991. Int. J. Radiat. Biol. 60, 73.
          Huang, R.C., et al. 1990. Mol. Pharmacol. 37, 304.
          Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50, 6490.
          Product Information
          CAS number129-46-4
          ATP CompetitiveN
          FormWhite crystalline solid
          Hill FormulaC₅₁H₃₄N₆O₂₃S₆ . 6Na
          Chemical formulaC₅₁H₃₄N₆O₂₃S₆ . 6Na
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetprotein tyrosine phosphatases
          Primary Target IC<sub>50</sub>15 µM against phospholipase D
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSQM7000000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Suramin, Sodium Salt - CAS 129-46-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Suramin, Sodium Salt - CAS 129-46-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          574625

          References

          Reference overview
          Meyers, M.O., et al. 2000. J. Surg. Res. 91, 130.
          Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
          Waldhoer, M., et al. 1998. Mol. Pharmacol. 53, 808.
          Zhang, Y.L., et al. 1998. J. Biol. Chem. 273, 12281.
          Hohenegger, M., et al. 1996. Mol. Pharmacol. 50, 1443.
          Emmick, J.J., et al. 1994. J. Pharmacol. Exp. Ther. 269, 717.
          Denhertog, A., et al. 1992. J. Physiol. 454, 591.
          Nakajima, M., et al. 1991. J. Biol. Chem. 266, 9661.
          Wilks, J.W., et al. 1991. Int. J. Radiat. Biol. 60, 73.
          Huang, R.C., et al. 1990. Mol. Pharmacol. 37, 304.
          Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50, 6490.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-May-2008 RFH
          SynonymsPTP Inhibitor VI, Purinergic Receptor P2Y Antagonist I, P2Y Antagonist I
          DescriptionAn anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerase I and II. Inhibits Ca2+-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC50 = 15 µM). Reported to interact with ATP-binding enzymes and P2-purinergic receptors. An effective inhibitor of angiogenesis in calmodulin assays when given in combination with angiostatic steroids.
          FormWhite crystalline solid
          CAS number129-46-4
          RTECSQM7000000
          Chemical formulaC₅₁H₃₄N₆O₂₃S₆ . 6Na
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 9006
          ReferencesMeyers, M.O., et al. 2000. J. Surg. Res. 91, 130.
          Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
          Waldhoer, M., et al. 1998. Mol. Pharmacol. 53, 808.
          Zhang, Y.L., et al. 1998. J. Biol. Chem. 273, 12281.
          Hohenegger, M., et al. 1996. Mol. Pharmacol. 50, 1443.
          Emmick, J.J., et al. 1994. J. Pharmacol. Exp. Ther. 269, 717.
          Denhertog, A., et al. 1992. J. Physiol. 454, 591.
          Nakajima, M., et al. 1991. J. Biol. Chem. 266, 9661.
          Wilks, J.W., et al. 1991. Int. J. Radiat. Biol. 60, 73.
          Huang, R.C., et al. 1990. Mol. Pharmacol. 37, 304.
          Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50, 6490.