569397 Staurosporine, Streptomyces sp.

569397
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₂₆N₄O₃ 62996-74-1

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      569397-100UG
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          Plastic ampoule 100 μg
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          569397-1MG
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              Plastic ampoule 1 mg
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              569397-250UG
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                  Plastic ampoule 250 μg
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                  Description
                  OverviewA potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits protein kinase A (IC50 = 7 nM), CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase C (IC50 = 700 pM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint. A 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569396) in DMSO is also available.
                  Catalogue Number569397
                  Brand Family Calbiochem®
                  SynonymsMLCK Inhibitor I, PKA Inhibitor II
                  References
                  ReferencesCouldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
                  Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
                  Bruno, S., et al. 1992. Cancer Res. 52, 470.
                  Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
                  Vitale, M.L., et al. 1992. Neuroscience 51, 463.
                  Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102.
                  Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.
                  Product Information
                  CAS number62996-74-1
                  ATP CompetitiveY
                  FormWhite to pale yellow solid
                  Hill FormulaC₂₈H₂₆N₄O₃
                  Chemical formulaC₂₈H₂₆N₄O₃
                  ReversibleY
                  Structure formula ImageStructure formula Image
                  Applications
                  Biological Information
                  Primary TargetPKA
                  Primary Target IC<sub>50</sub>7 nM, 20 nM, 1.3 nM, 700 pM, and 8.5 nM against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively
                  Purity≥99% by HPLC
                  Physicochemical Information
                  Cell permeableY
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage +2°C to +8°C
                  Protect from Light Protect from light
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
                  Packaging Information
                  Packaged under inert gas Packaged under inert gas
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  Staurosporine, Streptomyces sp. SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Staurosporine, Streptomyces sp. Certificates of Analysis

                  TitleLot Number
                  569397

                  References

                  Reference overview
                  Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
                  Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
                  Bruno, S., et al. 1992. Cancer Res. 52, 470.
                  Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
                  Vitale, M.L., et al. 1992. Neuroscience 51, 463.
                  Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102.
                  Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.

                  Citations

                  Title
                • Joao B. Oliveira, et al. (2007) NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Procedings of the National Academy of Science 104, 8953-8958.
                • Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530.
                • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision17-July-2014 JSW
                  SynonymsMLCK Inhibitor I, PKA Inhibitor II
                  DescriptionA potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.
                  FormWhite to pale yellow solid
                  Intert gas (Yes/No) Packaged under inert gas
                  CAS number62996-74-1
                  Chemical formulaC₂₈H₂₆N₄O₃
                  Structure formulaStructure formula
                  Purity≥99% by HPLC
                  SolubilityDMSO (5 mg/ml). Further dilute with aqueous buffers just prior to use.
                  Storage +2°C to +8°C
                  Protect from light
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
                  Toxicity Standard Handling
                  ReferencesCouldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
                  Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
                  Bruno, S., et al. 1992. Cancer Res. 52, 470.
                  Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
                  Vitale, M.L., et al. 1992. Neuroscience 51, 463.
                  Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102.
                  Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.
                  Citation
                • Joao B. Oliveira, et al. (2007) NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Procedings of the National Academy of Science 104, 8953-8958.
                • Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530.
                • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
                • Related Products & Applications

                  Categories

                  Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
                  Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
                  Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors