572630 SU5402 - CAS 215543-92-3 - Calbiochem

572630
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₆N₂O₃ 215543-92-3

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      572630-1MG
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          Plastic ampoule 1 mg
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          572630-2MG
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              Glass bottle 2 mg
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              572630-500UG
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                  Plastic ampoule 500 μg
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                  Description
                  OverviewA cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available.
                  Catalogue Number572630
                  Brand Family Calbiochem®
                  Synonyms3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
                  References
                  ReferencesMohammadi, M., et al. 1997. Science 276, 955.
                  Product Information
                  CAS number215543-92-3
                  ATP CompetitiveY
                  DeclarationNot available for sale in the United States.
                  FormLyophilized solid
                  Hill FormulaC₁₇H₁₆N₂O₃
                  Chemical formulaC₁₇H₁₆N₂O₃
                  ReversibleY
                  Structure formula ImageStructure formula Image
                  Applications
                  Biological Information
                  Primary TargetFibroblast growth factor receptor 1 (FGFR1)
                  Primary Target IC<sub>50</sub>10-20 &10-20 µM for fibroblast growth factor receptor 1 (FGFR1) in the presence of 1 mM ATP;M against FGFR1 in the presence of 1 mM ATP; 10-20 µM against inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2
                  Purity≥95% by HPLC
                  Physicochemical Information
                  Cell permeableY
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage +2°C to +8°C
                  Protect from Light Protect from light
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SU5402 - CAS 215543-92-3 - Calbiochem SDS

                  Title

                  Safety Data Sheet (SDS) 

                  SU5402 - CAS 215543-92-3 - Calbiochem Certificates of Analysis

                  TitleLot Number
                  572630

                  References

                  Reference overview
                  Mohammadi, M., et al. 1997. Science 276, 955.

                  Citations

                  Title
                • Marie-Claire Delfini, et al. (2005) Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proceedings of the National Academy of Science USA 102, 11343-11348.
                • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision19-April-2011 RFH
                  Synonyms3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
                  DescriptionA cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC50 = 10-20 µM in the presence of 1 mM ATP) by interacting with the catalytic domain of FGFR1. Also inhibits aFGF-induced phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984, it acts only as a weak inhibitor of tyrosine phosphorylation of the PDGF receptor. Does not inhibit the phosphorylation of insulin receptor and exhibits no inhibitory effect on EGF receptor kinase.
                  FormLyophilized solid
                  CAS number215543-92-3
                  Chemical formulaC₁₇H₁₆N₂O₃
                  Structure formulaStructure formula
                  Purity≥95% by HPLC
                  SolubilityDMSO (25 mg/ml)
                  Storage +2°C to +8°C
                  Protect from light
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
                  Toxicity Standard Handling
                  ReferencesMohammadi, M., et al. 1997. Science 276, 955.
                  Citation
                • Marie-Claire Delfini, et al. (2005) Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proceedings of the National Academy of Science USA 102, 11343-11348.
                • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.