531889 STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem

531889
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₄N₁₀O₁₃P₂ (free acid) 1441190-66-4

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      5.31889.0001
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          Glass bottle 500 μg
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          Description
          OverviewA cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4 nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 = 20 nM). Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1. Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′,2′-cGAMP, and 3′,3′-cGAMP and about 75 fold greater affinity over 2′,2′-cGAMP.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531889
          Brand Family Calbiochem®
          Synonymsc[G(2ʹ,5ʹ)pA(3ʹ,5ʹ)p], 2ʹ,5ʹ-3ʹ,5ʹ-cGAMP
          References
          ReferencesWu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
          Zhang, X., et al. 2013. Mol. Cell. 51, 226.
          Wu, J., et al. 2013. Science. 339, 26.
          Product Information
          CAS number1441190-66-4
          FormWhite solid
          Hill FormulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
          Chemical formulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Primary TargetSTING
          Primary Target K<sub>i</sub>4 nM, EC₅₀
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Wu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
          Zhang, X., et al. 2013. Mol. Cell. 51, 226.
          Wu, J., et al. 2013. Science. 339, 26.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-December-2014 JSW
          Synonymsc[G(2ʹ,5ʹ)pA(3ʹ,5ʹ)p], 2ʹ,5ʹ-3ʹ,5ʹ-cGAMP
          DescriptionA cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4 nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 = 20 nM). Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1. Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′,2′-cGAMP, and 3′,3′-cGAMP and about 75 fold greater affinity over 2′,2′-cGAMP.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1441190-66-4
          Chemical formulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
          Purity≥98% by HPLC
          SolubilityH₂O
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
          Zhang, X., et al. 2013. Mol. Cell. 51, 226.
          Wu, J., et al. 2013. Science. 339, 26.