573132 STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem

573132
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₉H₂₇F₅N₂O₆S 1334493-07-0

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      573132-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, orally bioavailable amidosalicylic acid compound that selectively binds the three subpockets of Stat3 SH2 domain surface (KD = 504 nM) and blocks Stat3 phosphorylation, dimerization, and DNA-binding activity in a dose-dependent manner. Preferentially disrupts the high affinity binding between Stat3 and IL-6R/gp130-derived pTyr904 peptide (IC50 = 4.1 µM). Does not exert any significant effect on the phosphorylation status of Shc, Src, JAK1/2, Erk1/2, or Akt. Shown to reduce Stat3-dependent growth, survival, migration, and invasion of tumor cells in vitro and suppress the growth of aberrant Stat3-harboring human breast and lung tumor xenografts (3 mg/kg, i,v. or o.g.) in vivo.
          Catalogue Number573132
          Brand Family Calbiochem®
          Synonyms4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
          References
          ReferencesZhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.
          Product Information
          CAS number1334493-07-0
          FormWhite powder
          Hill FormulaC₂₉H₂₇F₅N₂O₆S
          Chemical formulaC₂₉H₂₇F₅N₂O₆S
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationSTAT3 Inhibitor XVIII, BP-1-102, CAS 1334493-07-0, binds to the three subpockets of STAT3 SH2 domain and blocks STAT3 phosphorylation, dimerization, and DNA-binding activity.
          Biological Information
          Primary TargetStat3
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem Certificates of Analysis

          TitleLot Number
          573132

          References

          Reference overview
          Zhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2013 JSW
          Synonyms4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
          DescriptionA cell-permeable, orally bioavailable amidosalicylic acid compound that selectively binds the three subpockets of Stat3 SH2 domain surface (KD = 504 nM) and blocks Stat3 phosphorylation, dimerization, and DNA-binding activity in a dose-dependent manner. Preferentially disrupts the high affinity binding between Stat3 and IL-6R/gp130-derived pTyr904 peptide (IC50 = 4.1 µM). Does not exert any significant effect on the phosphorylation status of Shc, Src, JAK1/2, Erk1/2, or Akt. Shown to reduce Stat3-dependent growth, survival, migration, and invasion of tumor cells in vitro and suppress the growth of aberrant Stat3-harboring human breast and lung tumor xenografts (3 mg/kg, i,v. or o.g.) in vivo.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1334493-07-0
          Chemical formulaC₂₉H₂₇F₅N₂O₆S
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesZhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.