573102 STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem

573102
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₅NO₇S 501919-59-1

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      573102-10MG
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          Plastic ampoule 10 mg
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          573102-25MG
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              Description
              OverviewA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). Also available as a 50 mM solution in DMSO (Cat. No. 573130).
              Catalogue Number573102
              Brand Family Calbiochem®
              SynonymsNSC 74859, 2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid
              References
              ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
              Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.
              Product Information
              CAS number501919-59-1
              FormLight beige solid
              Hill FormulaC₁₆H₁₅NO₇S
              Chemical formulaC₁₆H₁₅NO₇S
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Purity≥95% by HPLC
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Regulatory Review
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem Certificates of Analysis

              TitleLot Number
              573102

              References

              Reference overview
              Lin, L., et al. 2009. Oncogene, 28, 961.
              Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision16-March-2009 RFH
              SynonymsNSC 74859, 2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid
              DescriptionA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.).
              FormLight beige solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number501919-59-1
              Chemical formulaC₁₆H₁₅NO₇S
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (10 mg/ml). Use only fresh, anhydrous DMSO.
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Regulatory Review
              ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
              Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.