508149 | SB 699551 Dihydrochloride - CAS 791789-61-2 - Calbiochem

508149
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₄H₄₅N₃O·2HCl 791789-61-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08149.0001
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          Glass bottle 10 mg
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          Description
          OverviewA selective, brain penetrant, 5-HT5A receptor antagonis (pKi = 8.2). Competitively antagonised 5-HT-stimulated [35S]GTPγS binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-HT5A receptor (pA2 8.1 ± 0.1) and displayed 100-fold selectivity versus the serotonin transporter and those 5-HT receptor subtypes (5-HT1A/B/D, 5-HT2A/C and 5-5-HT7).
          Catalogue Number508149
          Brand Family Calbiochem®
          Synonyms5-HT5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551
          References
          ReferencesFerenc, K. et al. 2012. Behav. Pharmacol. 23, 397.
          Thomas, D. R. et al. 2006. Neuropharmacol. 51, 566.
          Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett. 15, 4014.
          Product Information
          CAS number791789-61-2
          FormWhite solid
          Hill FormulaC₃₄H₄₅N₃O·2HCl
          Chemical formulaC₃₄H₄₅N₃O·2HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-HT5A
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Ferenc, K. et al. 2012. Behav. Pharmacol. 23, 397.
          Thomas, D. R. et al. 2006. Neuropharmacol. 51, 566.
          Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett. 15, 4014.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-October-2013 JSW
          Synonyms5-HT5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551
          DescriptionA selective, brain penetrant, 5-HT5A receptor antagonis (pKi = 8.2). Competitively antagonised 5-HT-stimulated [35S]GTPγS binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-HT5A receptor (pA2 8.1 ± 0.1) and displayed 100-fold selectivity versus the serotonin transporter and those 5-HT receptor subtypes (5-HT1A/B/D, 5-HT2A/C and 5-5-HT7).
          FormWhite solid
          CAS number791789-61-2
          Chemical formulaC₃₄H₄₅N₃O·2HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (25 mM) or Ethanol (10 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFerenc, K. et al. 2012. Behav. Pharmacol. 23, 397.
          Thomas, D. R. et al. 2006. Neuropharmacol. 51, 566.
          Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett. 15, 4014.