506415 | SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem

506415
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₈N₂O₃S·HCl 261901-57-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.06415.0001
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          Glass bottle 10 mg
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          Description
          OverviewA selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
          Catalogue Number506415
          Brand Family Calbiochem®
          Synonyms5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
          References
          ReferencesTokarski, K. et al. 2012. Pharmacol. Rep. 64, 256.
          Thomas. D. R. et al. 2000. Br. J. Pharmacol. 130, 409.
          Lovell, P. J. et al. 2000. J. Med. Chem. 43, 342.
          Forbes, I. T. et al. 1998. J. Med. Chem. 41, 655.
          Product Information
          CAS number 261901-57-9
          FormOff-white solid
          Hill FormulaC₁₈H₂₈N₂O₃S·HCl
          Chemical formulaC₁₈H₂₈N₂O₃S·HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-HT₇
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Tokarski, K. et al. 2012. Pharmacol. Rep. 64, 256.
          Thomas. D. R. et al. 2000. Br. J. Pharmacol. 130, 409.
          Lovell, P. J. et al. 2000. J. Med. Chem. 43, 342.
          Forbes, I. T. et al. 1998. J. Med. Chem. 41, 655.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2013 JSW
          Synonyms5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
          DescriptionA selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
          FormOff-white solid
          CAS number 261901-57-9
          Chemical formulaC₁₈H₂₈N₂O₃S·HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTokarski, K. et al. 2012. Pharmacol. Rep. 64, 256.
          Thomas. D. R. et al. 2000. Br. J. Pharmacol. 130, 409.
          Lovell, P. J. et al. 2000. J. Med. Chem. 43, 342.
          Forbes, I. T. et al. 1998. J. Med. Chem. 41, 655.