506272 | SB 206553 Hydrochloride - CAS 158942-04-2 - Calbiochem

506272
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₆N₄O·HCl 158942-04-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.06272.0001
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          Glass bottle 10 mg
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          Description
          OverviewA selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).
          Catalogue Number506272
          Brand Family Calbiochem®
          Synonyms5-HT2C Serotonin Receptor Antagonist, SB 206553, 5-HT2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553
          References
          ReferencesRos, R. et al. 2013. PNAS. 110, 348.
          Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
          Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol. 365, 242.
          Product Information
          CAS number158942-04-2
          FormYellow solid
          Hill FormulaC₁₇H₁₆N₄O·HCl
          Chemical formulaC₁₇H₁₆N₄O·HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-HT2C
          Primary Target K<sub>i</sub>3.2 nM
          Secondary target5-HT2B
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Ros, R. et al. 2013. PNAS. 110, 348.
          Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
          Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol. 365, 242.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2013 JSW
          Synonyms5-HT2C Serotonin Receptor Antagonist, SB 206553, 5-HT2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553
          DescriptionA selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).
          FormYellow solid
          CAS number158942-04-2
          Chemical formulaC₁₇H₁₆N₄O·HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesRos, R. et al. 2013. PNAS. 110, 348.
          Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
          Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol. 365, 242.