504637 | (S)-MCPG - CAS 150145-89-4 - Calbiochem

504637
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₁₁NO₄ 150145-89-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04637.0001
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          Glass bottle 10 mg
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          Description
          OverviewA non-selective antagonist for group I/II mGlu receptors (minimal values of IC50 reported = 40 and 15 µM for mGlu1 and mGlu2, respectively). Often used as an agent to differentiate excitatory neurotransmissions mediated by glutamate from other neurotransmitters (i.e. dopamine, acetylcholine, and GABA in early brain development). A common component of cocktails for blocking glutamate transmission in brain slice preparation.
          Catalogue Number504637
          Brand Family Calbiochem®
          Synonyms(S)-α-Methyl-4-carboxyphenylglycine, Group I/II mGlu Antagonist, (S)-MCPG
          References
          ReferencesFano, S., et al. 2012. Eur. J. Neurosci. 36, 3628.
          Wang, W., et al. 2012. J. Physiol. 590, 3743.
          Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646. Schoepp, D.D., et al. 1999.
          Neuropharmacol. 38, 1431.
          Product Information
          CAS number150145-89-4
          FormWhite solid
          Hill FormulaC₁₀H₁₁NO₄
          Chemical formulaC₁₀H₁₁NO₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGrup I and II mGlu receptors
          Primary Target IC<sub>50</sub>40 and 15 →M for mGlu₁ and mGlu₂, respectively.
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Fano, S., et al. 2012. Eur. J. Neurosci. 36, 3628.
          Wang, W., et al. 2012. J. Physiol. 590, 3743.
          Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646. Schoepp, D.D., et al. 1999.
          Neuropharmacol. 38, 1431.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-June-2013 JSW
          Synonyms(S)-α-Methyl-4-carboxyphenylglycine, Group I/II mGlu Antagonist, (S)-MCPG
          DescriptionA non-selective antagonist for group I/II mGlu receptors (minimal values of IC50 reported = 40 and 15 µM for mGlu1 and mGlu2, respectively). Often used as an agent to differentiate excitatory neurotransmissions mediated by glutamate from other neurotransmitters (i.e. dopamine, acetylcholine, and GABA in early brain development). A common component of cocktails for blocking glutamate transmission in brain slice preparation.
          FormWhite solid
          CAS number150145-89-4
          Chemical formulaC₁₀H₁₁NO₄
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O (10 mM) or DMSO (10 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFano, S., et al. 2012. Eur. J. Neurosci. 36, 3628.
          Wang, W., et al. 2012. J. Physiol. 590, 3743.
          Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646. Schoepp, D.D., et al. 1999.
          Neuropharmacol. 38, 1431.