531547 RyR1 Modulator, CCDI - Calbiochem

531547
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₈H₂₅N₃O

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31547.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable pyrrolo[1,2-c]imidazolone derived compound that selectively and preferentially binds to the cytoplasmic domain of mammalian ryanodine receptor 1 (RyR1) in a reversible manner and potentiates Ca2+-dependent binding of [3H]-ryanodine to RyR1(EC50 = 6 µM). Increases the open probability (Po) of RyR1 without affecting RyR2, RyR3, or the IP3R. Does not alter RyR1 conductance or the Kd for 3H-ryanodine binding to RyR1 in any significant manner (~4 nM vs 4.2 nM with and without CCDI in the medium). Induces Ca2+ transients in C2C12 skeletal myotubes, but does not alter Ca2+ transients in rat ventricular myocytes.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531547
          Brand Family Calbiochem®
          SynonymsRyanodine Receptor 1 Modulator
          References
          ReferencesTian, C., et al. 2014. Br. J. Pharmcol. 171, 4097.
          Product Information
          FormOff-white solid
          Hill FormulaC₁₈H₂₅N₃O
          Chemical formulaC₁₈H₂₅N₃O
          Applications
          Biological Information
          Primary TargetRyR1
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          RyR1 Modulator, CCDI - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Tian, C., et al. 2014. Br. J. Pharmcol. 171, 4097.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-October-2014 JSW
          SynonymsRyanodine Receptor 1 Modulator
          DescriptionA cell-permeable pyrrolo[1,2-c]imidazolone derived compound that selectively and preferentially binds to the cytoplasmic domain of mammalian ryanodine receptor 1 (RyR1) in a reversible manner and potentiates Ca2+-dependent binding of [3H]-ryanodine to RyR1(EC50 = 6 µM). Increases the open probability (Po) of RyR1 without affecting RyR2, RyR3, or the IP3R. Does not alter RyR1 conductance or the Kd for 3H-ryanodine binding to RyR1 in any significant manner (~4 nM vs 4.2 nM with and without CCDI in the medium). Induces Ca2+ transients in C2C12 skeletal myotubes, but does not alter Ca2+ transients in rat ventricular myocytes.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₈H₂₅N₃O
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTian, C., et al. 2014. Br. J. Pharmcol. 171, 4097.