557440 Ru360 - Calbiochem

557440
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂H₂₆Cl₃N₈O₅Ru₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      557440-1SET
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 1 set
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          557440-500UG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              Plastic ampoule 500 μg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              Description
              OverviewA cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM). Specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 µM of Ru360 for 30 min). Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction, even at micromolar levels.
              Note: 1 set = 10 x 100 µg.
              Catalogue Number557440
              Brand Family Calbiochem®
              Synonyms(μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃
              References
              ReferencesSanchez, J.A., et al. 2001. J. Physiol. 536, 387.
              Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
              Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
              Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
              Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
              Ying, W.-L., et al. 1991. Biochemistry 30, 4949.
              Product Information
              ATP CompetitiveN
              FormGreen solid
              Hill FormulaC₂H₂₆Cl₃N₈O₅Ru₂
              Chemical formulaC₂H₂₆Cl₃N₈O₅Ru₂
              Hygroscopic Hygroscopic
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetCa2+ uptake into mitochondria in vitro
              Primary Target IC<sub>50</sub>184 pM blocking Ca2+ uptake into mitochondria in vitro; and in situ in intact myocytes; Kd = 340 pM for binding mitochondria
              Purity≥97% by capillary electrophoresis
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsUnstable in solution; reconstitute just prior to use.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Ru360 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Ru360 - Calbiochem Certificates of Analysis

              TitleLot Number
              557440

              References

              Reference overview
              Sanchez, J.A., et al. 2001. J. Physiol. 536, 387.
              Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
              Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
              Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
              Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
              Ying, W.-L., et al. 1991. Biochemistry 30, 4949.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision09-August-2018 JSW
              Synonyms(μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃
              DescriptionA cell-permeable oxygen bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 0.34 nM) and specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (for complete block after incubation with ~10 µM of Ru360 for 30 min. Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction even at micromolar levels.
              FormGreen solid
              Intert gas (Yes/No) Packaged under inert gas
              Chemical formulaC₂H₂₆Cl₃N₈O₅Ru₂
              Structure formulaStructure formula
              Purity≥97% by capillary electrophoresis
              SolubilityDeoxygenated H₂O (0.5 mg/ml)
              Storage -20°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsUnstable in solution; reconstitute just prior to use.
              Toxicity Standard Handling
              ReferencesSanchez, J.A., et al. 2001. J. Physiol. 536, 387.
              Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
              Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
              Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
              Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
              Ying, W.-L., et al. 1991. Biochemistry 30, 4949.