557366 Rosiglitazone - CAS 155141-29-0 - Calbiochem

557366
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₉N₃O₃S.C₄H₄O₄ 155141-29-0

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      557366-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-g (PPARg) (Kd ~40 nM) in fat cells. Shown to reduce fatty acid uptake and ameliorate lipid metabolism and insulin resistance in animal models of type II diabetes. Reported to activate both a1- and a2-containing AMPK complexes. Unlike troglitazone, it does not induce the activity of P4503A4. Significantly improves the differentiation of C3H10T1/2 stem cells into adipocytes. Shown to block estrogen synthesis by interfering with androgen binding to aromatase, but without affecting aromatase mRNA or protein expression.
          Catalogue Number557366
          Brand Family Calbiochem®
          SynonymsPPAR Agonist X, PPARγ Agonist IX, 5-[4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl]thiazolidine-2,4-dione, BRL49653, Avandia, AMPK Signaling Activator X
          References
          ReferencesAraki, T., et al. 2011. PPAR Res. 2011, 926438.
          Sozio, M. S., et al. 2011. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G739.
          Gerstein, H., et al. 2006. Drug 368, 9541.
          Mohanty, P., 2004. Journ. Clin. Endocrin. & Metab. 89(6), 2728-2735.
          Fryer, L., et al. 2002. J Biol Chem 277, 25226.
          Goldberg, R., et al. 1999. Drug. 57, 921.
          Young, P., et al. 1998. Journ. Pharm. Exp. Ther. 284, 751.
          Willson, T., et al. 1996. J. Med. Chem.39, 665; Lehmann, J., et al., 1995. JBC 270, 12953.
          Cantello, B., et al., 1994. Bioorg. Med. Chem. Lett. 4, 1181.
          Product Information
          CAS number155141-29-0
          FormWhite powder
          Hill FormulaC₁₈H₁₉N₃O₃S.C₄H₄O₄
          Chemical formulaC₁₈H₁₉N₃O₃S.C₄H₄O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Rosiglitazone - CAS 155141-29-0 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Rosiglitazone - CAS 155141-29-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          557366

          References

          Reference overview
          Araki, T., et al. 2011. PPAR Res. 2011, 926438.
          Sozio, M. S., et al. 2011. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G739.
          Gerstein, H., et al. 2006. Drug 368, 9541.
          Mohanty, P., 2004. Journ. Clin. Endocrin. & Metab. 89(6), 2728-2735.
          Fryer, L., et al. 2002. J Biol Chem 277, 25226.
          Goldberg, R., et al. 1999. Drug. 57, 921.
          Young, P., et al. 1998. Journ. Pharm. Exp. Ther. 284, 751.
          Willson, T., et al. 1996. J. Med. Chem.39, 665; Lehmann, J., et al., 1995. JBC 270, 12953.
          Cantello, B., et al., 1994. Bioorg. Med. Chem. Lett. 4, 1181.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-August-2012 JSW
          SynonymsPPAR Agonist X, PPARγ Agonist IX, 5-[4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl]thiazolidine-2,4-dione, BRL49653, Avandia, AMPK Signaling Activator X
          DescriptionA thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-g (PPARg) (Kd ~40 nM) in fat cells. Shown to reduce fatty acid uptake and ameliorate lipid metabolism and insulin resistance in animal models of type II diabetes. Reported to activate both a1- and a2-containing AMPK complexes. Unlike troglitazone, it does not induce the activity of P4503A4. Significantly improves the differentiation of C3H10T1/2 stem cells into adipocytes. Shown to block estrogen synthesis by interfering with androgen binding to aromatase, but without affecting aromatase mRNA or protein expression.
          FormWhite powder
          CAS number155141-29-0
          Chemical formulaC₁₈H₁₉N₃O₃S.C₄H₄O₄
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAraki, T., et al. 2011. PPAR Res. 2011, 926438.
          Sozio, M. S., et al. 2011. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G739.
          Gerstein, H., et al. 2006. Drug 368, 9541.
          Mohanty, P., 2004. Journ. Clin. Endocrin. & Metab. 89(6), 2728-2735.
          Fryer, L., et al. 2002. J Biol Chem 277, 25226.
          Goldberg, R., et al. 1999. Drug. 57, 921.
          Young, P., et al. 1998. Journ. Pharm. Exp. Ther. 284, 751.
          Willson, T., et al. 1996. J. Med. Chem.39, 665; Lehmann, J., et al., 1995. JBC 270, 12953.
          Cantello, B., et al., 1994. Bioorg. Med. Chem. Lett. 4, 1181.