557525 Ro-32-0432 - CAS 145333-02-4 - Calbiochem

557525
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₂₈N₄O₂ · HCl 145333-02-4

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      557525-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over PKCε (IC50 = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number557525
          Brand Family Calbiochem®
          Synonyms2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
          References
          ReferencesBirchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
          Product Information
          CAS number145333-02-4
          ATP CompetitiveN
          FormRed solid
          Hill FormulaC₂₈H₂₈N₄O₂ · HCl
          Chemical formulaC₂₈H₂₈N₄O₂ · HCl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKCα
          Primary Target IC<sub>50</sub>9 nM, 28 nM, 108 nM, against PKCα, PKCβI, and PKCε, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ro-32-0432 - CAS 145333-02-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Ro-32-0432 - CAS 145333-02-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          557525

          References

          Reference overview
          Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

          Citations

          Title
        • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-October-2014 JSW
          Synonyms2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
          DescriptionA selective cell-permeable protein kinase C inhibitor. Displays about a 10-fold greater selectivity for PKCα (IC50 = 9 nM) and a 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over PKCε (IC50 = 108 nM). Also prevents T-cell driven chronic inflammatory responses in vivo.
          FormRed solid
          CAS number145333-02-4
          Chemical formulaC₂₈H₂₈N₄O₂ · HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesBirchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
          Citation
        • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.