504845 Ro 25-6981 Maleate Salt - CAS 169274-78-6 - Calbiochem

504845
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₉NO₂•C₄H₄O₄ 169274-78-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04845.0001
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          Glass bottle 1 mg
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          Description
          OverviewA potent, activity-dependent antagonist highly selective for GluN1/NR2B subtype NMDA receptors (IC50 = 0.009 and 52 µM for NR2B and NR2A subtype receptors respectively). Commonly used for studying brain functions and disorders involving neurotransmissions mediated by GluN1/NR2B subtype NMDA receptors (learning and memory, neuroplasticity, neurotoxicity, neuropathic pain, addiction, and neurogenesis enhancement).
          Catalogue Number504845
          Brand Family Calbiochem®
          Synonyms[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
          References
          ReferencesQi, Y., et al. 2013. Cereb. Cortex. 23, 932.
          Soloviova, A., et al. 2012. Exp. Biol. & Med. 153, 764.
          Solovyeva, A., et al. 2012. Neurosci. & Behav. Physiol. 42, 456.
          Chazot, L., et al. 2004. Curr. Med. Chem. 11, 389.
          Lynch, R., et al. 2001. Eur. J. Pharmacol. 416, 185.
          Fischer, G., et al. 1997. J. Pharmacol. Exp. Ther. 283, 1285.
          Product Information
          CAS number169274-78-6
          FormWhite solid
          Hill FormulaC₂₂H₂₉NO₂•C₄H₄O₄
          Chemical formulaC₂₂H₂₉NO₂•C₄H₄O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGluN1/NR2B receptors
          Primary Target IC<sub>50</sub>0.009 →M
          Purity≥99% by Chiral HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Qi, Y., et al. 2013. Cereb. Cortex. 23, 932.
          Soloviova, A., et al. 2012. Exp. Biol. & Med. 153, 764.
          Solovyeva, A., et al. 2012. Neurosci. & Behav. Physiol. 42, 456.
          Chazot, L., et al. 2004. Curr. Med. Chem. 11, 389.
          Lynch, R., et al. 2001. Eur. J. Pharmacol. 416, 185.
          Fischer, G., et al. 1997. J. Pharmacol. Exp. Ther. 283, 1285.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-July-2013 JSW
          Synonyms[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
          DescriptionA potent, activity-dependent antagonist highly selective for GluN1/NR2B subtype NMDA receptors (IC50 = 0.009 and 52 µM for NR2B and NR2A subtype receptors respectively). Commonly used for studying brain functions and disorders involving neurotransmissions mediated by GluN1/NR2B subtype NMDA receptors (learning and memory, neuroplasticity, neurotoxicity, neuropathic pain, addiction, and neurogenesis enhancement).
          FormWhite solid
          CAS number169274-78-6
          Chemical formulaC₂₂H₂₉NO₂•C₄H₄O₄
          Structure formulaStructure formula
          Purity≥99% by Chiral HPLC
          SolubilityH₂O (25 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesQi, Y., et al. 2013. Cereb. Cortex. 23, 932.
          Soloviova, A., et al. 2012. Exp. Biol. & Med. 153, 764.
          Solovyeva, A., et al. 2012. Neurosci. & Behav. Physiol. 42, 456.
          Chazot, L., et al. 2004. Curr. Med. Chem. 11, 389.
          Lynch, R., et al. 2001. Eur. J. Pharmacol. 416, 185.
          Fischer, G., et al. 1997. J. Pharmacol. Exp. Ther. 283, 1285.