557451 RXRα Inhibitor, K-80003 - Calbiochem

557451
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₂₃FO₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      557451-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable, Sulindac analog with IC50=2.4 µM for RXRα binding, and unlike other NSAIDs, is inactive toward COX2 and COX1 even at 1 mM. The compound displays potent inhibition of RXRα dependent AKT Activation in both PC3 and A549 cells, and is RXRα but not RXRγ expression dependent as shown in PC3 cells. It is further shown to inhibit the interaction of RXRα/Δ80 with p85α either in the absence or presence of TNF-α. Induces PARP cleavage and caspase-8 activation at 50 µM when used with TNF-α. Furthermore, it almost completely suppresses colony formation of HeLa/RXRα/1-134 and RXRα/Δ80 cells at 25 µM in vitro, and exhibits potent inhibition of tumor growth in vivo when dosed at 60mg/kg.
          Catalogue Number557451
          Brand Family Calbiochem®
          SynonymsK-80003
          References
          ReferencesZhou, H., et al. 2010. Cancer Cell 17, 560.
          Product Information
          FormYellow solid
          Hill FormulaC₂₃H₂₃FO₂
          Chemical formulaC₂₃H₂₃FO₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          RXRα Inhibitor, K-80003 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          RXRα Inhibitor, K-80003 - Calbiochem Certificates of Analysis

          TitleLot Number
          557451

          References

          Reference overview
          Zhou, H., et al. 2010. Cancer Cell 17, 560.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-February-2011 RFH
          SynonymsK-80003
          DescriptionA cell permeable, Sulindac analog with IC50=2.4 µM for RXRα binding, and unlike other NSAIDs, is inactive toward COX2 and COX1 even at 1 mM. The compound displays potent inhibition of RXRα dependent AKT Activation in both PC3 and A549 cells, and is RXRα but not RXRγ expression dependent as shown in PC3 cells. It is further shown to inhibit the interaction of RXRα/Δ80 with p85α either in the absence or presence of TNF-α. Induces PARP cleavage and caspase-8 activation at 50 µM when used with TNF-α. Furthermore, it almost completely suppresses colony formation of HeLa/RXRα/1-134 and RXRα/Δ80 cells at 25 µM in vitro, and exhibits potent inhibition of tumor growth in vivo when dosed at 60 mg/kg.
          FormYellow solid
          Chemical formulaC₂₃H₂₃FO₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.
          Toxicity Standard Handling
          ReferencesZhou, H., et al. 2010. Cancer Cell 17, 560.