559285 RSK Inhibitor, SL0101

559285
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₂₄O₁₂ 77307-50-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      559285-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. Also available as a 10 mM solution in DMSO (Cat. No. 559292).
          Catalogue Number559285
          Brand Family Calbiochem®
          SynonymsKaempferol-3-O-(3ʹʹ,4ʹʹ-di-O-acetyl-α-L-rhamnopyranoside), p90 Ribosomal S6 Kinase Inhibitor, SL0101
          References
          ReferencesSmith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
          Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
          Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
          Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
          Smith, J.A., et al. 2005. Cancer Res. 65, 1027.
          Product Information
          CAS number77307-50-7
          FormYellow solid
          Hill FormulaC₂₅H₂₄O₁₂
          Chemical formulaC₂₅H₂₄O₁₂
          Structure formula ImageStructure formula Image
          Applications
          ApplicationRSK Inhibitor, SL0101, CAS 77307-50-7, is a cell-permeable, selective, reversible, ATP-competitive RSK inhibitor (IC50 = 89 nM with 10 µM ATP). Blocks the proliferation of MCF-7 cell line.
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          RSK Inhibitor, SL0101 SDS

          Title

          Safety Data Sheet (SDS) 

          RSK Inhibitor, SL0101 Certificates of Analysis

          TitleLot Number
          559285

          References

          Reference overview
          Smith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
          Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
          Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
          Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
          Smith, J.A., et al. 2005. Cancer Res. 65, 1027.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2014 JSW
          SynonymsKaempferol-3-O-(3ʹʹ,4ʹʹ-di-O-acetyl-α-L-rhamnopyranoside), p90 Ribosomal S6 Kinase Inhibitor, SL0101
          DescriptionA cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number77307-50-7
          Chemical formulaC₂₅H₂₄O₁₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Regulatory Review
          ReferencesSmith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
          Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
          Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
          Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
          Smith, J.A., et al. 2005. Cancer Res. 65, 1027.