557403 RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem

557403
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₅Cl₂N₃O₂S₂ 577784-91-9

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      557403-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).
          Catalogue Number557403
          Brand Family Calbiochem®
          SynonymsML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide
          References
          ReferencesWu, L., et al. 2003. Euk. Cell 2, 256.
          Product Information
          CAS number577784-91-9
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₉H₁₅Cl₂N₃O₂S₂
          Chemical formulaC₁₉H₁₅Cl₂N₃O₂S₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetactivity against RNA Polymerase III
          Primary Target IC<sub>50</sub>27 and 32 µM for Human and S. cerevisiae RNA Pol III
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          557403

          References

          Reference overview
          Wu, L., et al. 2003. Euk. Cell 2, 256.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          SynonymsML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide
          DescriptionA cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number577784-91-9
          Chemical formulaC₁₉H₁₅Cl₂N₃O₂S₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (15 mg/ml). Slight warming may be necessary to achieve complete solubilization.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesWu, L., et al. 2003. Euk. Cell 2, 256.