554718 REV-ERBα Antagonist, SR8278 - Calbiochem

554718
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₈H₁₉NO₃S₂₃

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      554718-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
          Catalogue Number554718
          Brand Family Calbiochem®
          SynonymsSR8278 SR 8278
          References
          ReferencesKojetin, D., et al. 2010, Chem Bio in press
          Product Information
          FormWhite to yellow-brown solid or gum
          Hill FormulaC₁₈H₁₉NO₃S₂₃
          Chemical formulaC₁₈H₁₉NO₃S₂₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity>95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          REV-ERBα Antagonist, SR8278 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          REV-ERBα Antagonist, SR8278 - Calbiochem Certificates of Analysis

          TitleLot Number
          554718

          References

          Reference overview
          Kojetin, D., et al. 2010, Chem Bio in press
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-September-2016 JSW
          SynonymsSR8278 SR 8278
          DescriptionA cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
          FormWhite to yellow-brown solid or gum
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₈H₁₉NO₃S₂₃
          Structure formulaStructure formula
          Purity>95% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
          Toxicity Regulatory Review
          ReferencesKojetin, D., et al. 2010, Chem Bio in press