523310 | Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem

523310
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₆O₃ 537-42-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      523310-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, antiproliferative, and hypoglycemic properties. Moderately inhibits COX-1 and -2 activities (IC50 = 19.8 µM and 83.9 µM) respectively, induces apoptosis in HL60 cells (IC50 = 70 µM), prevents DMBA-induced preneoplastic lesions (ED50 = 4.8 µM) and decreases plasma glucose level in streptozotocin-induced diabetic rats comparable to that of Metformin.
          Catalogue Number523310
          Brand Family Calbiochem®
          Synonymstrans-3,5-Dimethoxy-4ʹ-hydroxystilbene
          References
          ReferencesRoberti, M., et al. 2003. J. Med. Chem. 46, 3546.
          Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453.
          Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.
          Product Information
          CAS number537-42-8
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₆H₁₆O₃
          Chemical formulaC₁₆H₁₆O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCOX-1 and COX-2 activities
          Primary Target IC<sub>50</sub>19.8 µM, 83.9 µM against COX-1 and -2 activities, respectively; 70 µM for inducing apoptosis in HL60 cells; ED50 = 4.8 µM for preventing DMBA-induced preneoplastic lesions
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          523310

          References

          Reference overview
          Roberti, M., et al. 2003. J. Med. Chem. 46, 3546.
          Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453.
          Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-October-2007 JSW
          Synonymstrans-3,5-Dimethoxy-4ʹ-hydroxystilbene
          DescriptionA cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox® (Cat. No. 64847). Moderately inhibits COX-1 & COX-2 activities (IC50 = 19.8 µM & 83.9 µM, respectively) and induces apoptosis in HL60 cells (IC50 = 70 µM). Also prevents DMBA-induced pre-neoplastic lesions (ED50 = 4.8 µM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number537-42-8
          Chemical formulaC₁₆H₁₆O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Methanol (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesRoberti, M., et al. 2003. J. Med. Chem. 46, 3546.
          Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453.
          Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.