508514 | Psalmotoxin-1 - Calbiochem

508514
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₀₀H₃₁₂N₆₂O₅₇S₆

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08514.0001
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          Glass bottle 20 μg
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          Description
          OverviewA potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.
          Catalogue Number508514
          Brand Family Calbiochem®
          SynonymsASIC1a Inhibitor, Psalmotoxin 1
          References
          ReferencesQadri, Y. J. et al. 2009. J. Biol. Chem. 284, 17625.
          M. Mazzuca, et al. 2007. Nat Neurosci. 10, 943.
          Escoubas, P. et al. 2000. J. Biol. Chem. 275, 25116.
          Product Information
          FormColorless semi-solid to viscous liquid
          Hill Formula C₂₀₀H₃₁₂N₆₂O₅₇S₆
          Chemical formulaC₂₀₀H₃₁₂N₆₂O₅₇S₆
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Primary TargetASIC1a
          Primary Target IC<sub>50</sub>0.9 nM
          Purity≥95% by HPLC
          Physicochemical Information
          Peptide SequenceEDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Qadri, Y. J. et al. 2009. J. Biol. Chem. 284, 17625.
          M. Mazzuca, et al. 2007. Nat Neurosci. 10, 943.
          Escoubas, P. et al. 2000. J. Biol. Chem. 275, 25116.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-September-2017 JSW
          SynonymsASIC1a Inhibitor, Psalmotoxin 1
          DescriptionA potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.
          FormColorless semi-solid to viscous liquid
          Chemical formulaC₂₀₀H₃₁₂N₆₂O₅₇S₆
          Peptide SequenceEDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)
          Purity≥95% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesQadri, Y. J. et al. 2009. J. Biol. Chem. 284, 17625.
          M. Mazzuca, et al. 2007. Nat Neurosci. 10, 943.
          Escoubas, P. et al. 2000. J. Biol. Chem. 275, 25116.