539211 Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem

539211
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₉H₆Br₄O₅Na₂ • 3H₂O 17372-87-1

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      539211-50MG
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          Plastic ampoule 50 mg
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          Description
          OverviewA xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 and 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 and Suv39H2).
          Catalogue Number539211
          Brand Family Calbiochem®
          SynonymsDisodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
          References
          ReferencesCheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
          Product Information
          CAS number17372-87-1
          FormReddish brown solid
          Hill FormulaC₂₉H₆Br₄O₅Na₂ • 3H₂O
          Chemical formulaC₂₉H₆Br₄O₅Na₂ • 3H₂O
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥90%
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 24/25-36/37/39-45

          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          539211

          References

          Reference overview
          Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-May-2009 RFH
          SynonymsDisodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
          DescriptionA xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).
          FormReddish brown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number17372-87-1
          Chemical formulaC₂₉H₆Br₄O₅Na₂ • 3H₂O
          Structure formulaStructure formula
          Purity≥90%
          SolubilityH₂O (50 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesCheng, D., et al. 2004. J. Biol. Chem. 279, 23892.