539175 Proteasome Inhibitor IV - Calbiochem

539175
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₀H₃₈N₄O₆

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      539175-5MG
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      Stocked 
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          Plastic ampoule 5 mg
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          Description
          OverviewA tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity). Shown to be a weak inhibitor of trypsin-like proteasomal activity.
          Catalogue Number539175
          Brand Family Calbiochem®
          SynonymsZ-GPFL-CHO
          References
          ReferencesOberdorf, J., et al. 2001. Biochemistry 40, 13397.
          Cardozo, C., et al. 1999. Biochemistry 38, 9768.
          Eleuteri, A.M., et al. 1997. J. Biol. Chem. 272, 11824.
          Orlowski, M., et al. 1997. Biochemistry 36, 13946.
          Vinitsky, A., et al. 1994. J. Biol. Chem. 269, 29860.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₃₀H₃₈N₄O₆
          Chemical formulaC₃₀H₃₈N₄O₆
          ReversibleN
          Applications
          Biological Information
          Primary Targetbranched chain amino acid preferring,small neutral amino acid preferring, chymotrypsin-like activities
          Primary Target K<sub>i</sub>1.5 µM, 2.3 µM, and 40.5 µM against branched chain amino acid preferring, small neutral amino acid preferring, and chymotrypsin-like activities of proteasomes, respectively
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceZ-Gly-Pro-Phe-Leu-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Proteasome Inhibitor IV - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Proteasome Inhibitor IV - Calbiochem Certificates of Analysis

          TitleLot Number
          539175

          References

          Reference overview
          Oberdorf, J., et al. 2001. Biochemistry 40, 13397.
          Cardozo, C., et al. 1999. Biochemistry 38, 9768.
          Eleuteri, A.M., et al. 1997. J. Biol. Chem. 272, 11824.
          Orlowski, M., et al. 1997. Biochemistry 36, 13946.
          Vinitsky, A., et al. 1994. J. Biol. Chem. 269, 29860.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-October-2009 RFH
          SynonymsZ-GPFL-CHO
          DescriptionA tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity). Shown to be a weak inhibitor of trypsin-like proteasomal activity.
          FormWhite lyophilized solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₀H₃₈N₄O₆
          Peptide SequenceZ-Gly-Pro-Phe-Leu-CHO
          Purity≥90% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesOberdorf, J., et al. 2001. Biochemistry 40, 13397.
          Cardozo, C., et al. 1999. Biochemistry 38, 9768.
          Eleuteri, A.M., et al. 1997. J. Biol. Chem. 272, 11824.
          Orlowski, M., et al. 1997. Biochemistry 36, 13946.
          Vinitsky, A., et al. 1994. J. Biol. Chem. 269, 29860.