504819 Porcn Inhibitor III, IWP-L6 - CAS 1427782-89-6 - Calbiochem

504819
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₂₀N₄O₂S₂ 1427782-89-6

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04819.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable pyridinyl-phenylacetamide that is reported to be 60-times more potent than IWP-2 (Cat. No. 681671) in suppressing autonomous Wnt signaling in murine L-Wnt-STF fibroblasts (IC50 = 0.5 nM) and 100-times more potent in blocking branching morphogenesis in cultured murine embryonic kidney (complete blockage at 50 nM). Also shown to be at least twice as potent as TNKS inhibitor IWR-1 (Cat. No. 681669) in preventing the regeneration of severed zebrafish tailfin and in inhibiting zebrafish embryo prosterior axis formation (Effective conc = 5 µM). Its susceptibility to metabolization by serum carboxylesterase limits its in vivo use in rats and mice.
          Catalogue Number504819
          Brand Family Calbiochem®
          SynonymsIWPL6, Wnt Pathway Inhibitor XIX
          References
          ReferencesWang, X., et al. 2013. J. Med. Chem. 56, 2700.
          Product Information
          CAS number1427782-89-6
          FormOff-white solid
          Hill FormulaC₂₅H₂₀N₄O₂S₂
          Chemical formulaC₂₅H₂₀N₄O₂S₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPorcupine
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Wang, X., et al. 2013. J. Med. Chem. 56, 2700.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-December-2013 JSW
          SynonymsIWPL6, Wnt Pathway Inhibitor XIX
          DescriptionA cell-permeable, benzothiazole-to-5-phenylpyridin substituted IWP-2 (Cat. No. 681671) derivative that is reported to be 60-times more potent than IWP-2 in suppressing autonomous Wnt signaling in murine L-Wnt-STF fibroblasts (IC50 = 0.5 vs. 30 nM) and 100-times more potent in blocking Wnt signaling-mediated branching morphogenesis in cultured murine embryonic kidneys (complete blockage with 50 nM IWP-L6 or 5 µM IWP-2). Also shown to be at least twice as potent as TNKS inhibitor IWR-1 (Cat. No. 681669) in preventing the regeneration of severed zebrafish tailfin and in inhibiting zebrafish embryo prosterior axis formation (Effective conc = 5 µM). Its susceptibility to metabolization by serum carboxylesterase limits its in vivo use in rats and mice (t1/2 = 2 and 190 min, respectively, in murine or rat plasma).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1427782-89-6
          Chemical formulaC₂₅H₂₀N₄O₂S₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWang, X., et al. 2013. J. Med. Chem. 56, 2700.