506132 | Pifithrin-α - CAS 63208-82-2 - Calbiochem

506132
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₈N₂OS·HBr 63208-82-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506132-10MG
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          Plastic ampoule 10 mg
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          506132-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.
              Catalogue Number506132
              Brand Family Calbiochem®
              Synonyms2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
              References
              ReferencesMurphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
              Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
              Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
              Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
              Ferber, D. 1999. Science 285, 1651.
              Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
              Komarov, P.G., et al. 1999. Science 285, 1733.
              Product Information
              CAS number63208-82-2
              ATP CompetitiveN
              FormOff-white solid
              Hill FormulaC₁₆H₁₈N₂OS·HBr
              Chemical formulaC₁₆H₁₈N₂OS·HBr
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetPS3
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              506132

              References

              Reference overview
              Murphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
              Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
              Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
              Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
              Ferber, D. 1999. Science 285, 1651.
              Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
              Komarov, P.G., et al. 1999. Science 285, 1733.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision03-April-2008 RFH
              Synonyms2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
              DescriptionA reversible inhibitor of p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects mice from lethal genotoxic stress associated with anticancer treatment without promoting tumor formation. Has been reported to protect neurons against β-amyloid and glutamate-induced apoptosis.
              FormOff-white solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number63208-82-2
              Chemical formulaC₁₆H₁₈N₂OS·HBr
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (100 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
              Toxicity Standard Handling
              ReferencesMurphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
              Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
              Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
              Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
              Ferber, D. 1999. Science 285, 1651.
              Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
              Komarov, P.G., et al. 1999. Science 285, 1733.