528105 | Picrotoxin, Anamirta cocculin - CAS 124-87-8 - Calbiochem

528105
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₈O₇ . C₁₅H₁₆O₆ 124-87-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      528105-100MG
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          100 mg
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          Description
          OverviewA potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system. Inhibits 35S-TBPS binding to the Cl channel (IC50 = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.
          Catalogue Number528105
          Brand Family Calbiochem®
          References
          ReferencesQian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
          Yoon, K.W., et al. 1993. J. Physiol. 464, 423.
          Akaike, N., et al. 1985. Experientia 41, 70.
          Product Information
          CAS number124-87-8
          ATP CompetitiveN
          FormWhite fine crystalline solid
          Hill FormulaC₁₅H₁₈O₇ . C₁₅H₁₆O₆
          Chemical formulaC₁₅H₁₈O₇ . C₁₅H₁₆O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGABA receptors
          Primary Target IC<sub>50</sub>240 nM against GABA receptors
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSTJ9100000
          Safety Information
          R PhraseR: 26/27/28

          Very toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          528105

          References

          Reference overview
          Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
          Yoon, K.W., et al. 1993. J. Physiol. 464, 423.
          Akaike, N., et al. 1985. Experientia 41, 70.

          Brochure

          Title
          Channel Blockers Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-September-2014 JSW
          DescriptionA potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system. Inhibits 35S-TBPS binding to the Cl- channel (IC50 = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.
          FormWhite fine crystalline solid
          CAS number124-87-8
          RTECSTJ9100000
          Chemical formulaC₁₅H₁₈O₇ . C₁₅H₁₆O₆
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityEthanol (50 mg/ml) or basic aqueous solutions (3 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Toxicity Highly Toxic
          Merck USA index14, 7415
          ReferencesQian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
          Yoon, K.W., et al. 1993. J. Physiol. 464, 423.
          Akaike, N., et al. 1985. Experientia 41, 70.