525276 | Phosphoramidon, Disodium Salt - Calbiochem

525276
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₃₂N₃O₁₀P · 2Na

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      525276-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewInhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Inhibits the conversion of big endothelin-1 to endothelin (IC50 = 4.6 µM).
          Effective concentration: 1-10 µM.
          Catalogue Number525276
          Brand Family Calbiochem®
          SynonymsN-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na
          References
          ReferencesBalwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
          Howell, S., et al. 1993. Biochem. J. 290, 159.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₂₃H₃₂N₃O₁₀P · 2Na
          Chemical formulaC₂₃H₃₂N₃O₁₀P · 2Na
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary Targetthermolysin
          Primary Target IC<sub>50</sub>4.6 µM against the conversion of big endothelin-1 to endothelin
          PuritySingle spot by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          525276

          References

          Reference overview
          Balwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
          Howell, S., et al. 1993. Biochem. J. 290, 159.

          Citations

          Title
        • Peter Oishi, et al. (2006) Nitric Oxide-Endothelin-1 Interactions After Surgically Induced Acute Increases in Pulmonary Blood Flow in the Intact Lamb. American Journal of Physiology Heart and Circulatory Physiology 290, H1922-1932.
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-August-2008 RFH
          SynonymsN-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na
          DescriptionInhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Inhibits the conversion of big endothelin-1 to endothelin (IC50 = 4.6 µM).
          FormWhite lyophilized solid
          Chemical formulaC₂₃H₃₂N₃O₁₀P · 2Na
          PuritySingle spot by TLC
          SolubilityDMSO (10 mg/ml), methanol, or H₂O
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesBalwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
          Howell, S., et al. 1993. Biochem. J. 290, 159.
          Citation
        • Peter Oishi, et al. (2006) Nitric Oxide-Endothelin-1 Interactions After Surgically Induced Acute Increases in Pulmonary Blood Flow in the Intact Lamb. American Journal of Physiology Heart and Circulatory Physiology 290, H1922-1932.
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.