524736 | Phosphodiesterase 4B2, His•Tag®, Human, Recombinant, S. frugiperda

524736
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      524736-10U
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 10 u
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          Description
          OverviewFull-length, recombinant, human phosphodiesterase 4B2 (accession no. L20971) fused at the N-terminus to a His•Tag® sequence and expressed in S. frugiperda using a baculovirus expression system. Plays a significant role in the regulation of inflammatory cell activation. PDE4B2 is a predominant isoform in neutrophils and monocytes. Supplied as a partially purified, catalytically active preparation.
          Catalogue Number524736
          Brand Family Calbiochem®
          SynonymsPDE4B2, cAMP-Specific Phosphodiesterase 4B2
          Application Data
          Phosphodiesterase 4B2 was treated with increasing concentrations of the inhibitor, rolipram, and the activity assayed. the IC50 for this inhibition is 1.77 µM.
          References
          ReferencesGibson, L.C.D., et al. 2006. Eur. J. Pharmacol. 538, 39.
          Smith, P.G., et al. 2005 Blood 105, 308.
          Baroja, M.L., et al. 1999. J. Immunol. 162, 2016.
          Product Information
          Activity≥ 0.25 units/µl
          Unit of DefinitionOne unit is defined as the amount of enzyme that will convert 1 pmol cAMP to AMP per min at 30°C, pH 7.5.
          FormLiquid
          FormulationIn 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3.
          Applications
          Biological Information
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          524736

          References

          Reference overview
          Gibson, L.C.D., et al. 2006. Eur. J. Pharmacol. 538, 39.
          Smith, P.G., et al. 2005 Blood 105, 308.
          Baroja, M.L., et al. 1999. J. Immunol. 162, 2016.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-March-2009 JSW
          SynonymsPDE4B2, cAMP-Specific Phosphodiesterase 4B2
          Application Data
          Phosphodiesterase 4B2 was treated with increasing concentrations of the inhibitor, rolipram, and the activity assayed. the IC50 for this inhibition is 1.77 µM.
          DescriptionFull-length, recombinant, human phosphodiesterase 4B2 (accession no. L20971) fused at the N-terminus to a His•Tag® sequence and expressed in S. frugiperda using a baculovirus expression system. Plays a significant role in the regulation of inflammatory cell activation. PDE4B2 is a predominant isoform in neutrophils and monocytes. Supplied as a partially purified, catalytically active preparation.
          FormLiquid
          FormulationIn 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3.
          Activity≥ 0.25 units/µl
          Unit definitionOne unit is defined as the amount of enzyme that will convert 1 pmol cAMP to AMP per min at 30°C, pH 7.5.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesGibson, L.C.D., et al. 2006. Eur. J. Pharmacol. 538, 39.
          Smith, P.G., et al. 2005 Blood 105, 308.
          Baroja, M.L., et al. 1999. J. Immunol. 162, 2016.