52332 | Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem

52332
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₇FO₂S 329-98-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      52332-1GM
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          Alu drum 1 gm
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          52332-25GM
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              Fibre case 25 gm
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              52332-5GM
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                  Glass bottle 5 gm
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                  Description
                  OverviewIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).
                  Catalogue Number52332
                  Brand Family Calbiochem®
                  SynonymsBenzylsulfonyl Fluoride, PMSF
                  References
                  ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
                  Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
                  Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
                  Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
                  Product Information
                  CAS number329-98-6
                  ATP CompetitiveN
                  FormWhite to off-white crystalline solid
                  Hill FormulaC₇H₇FO₂S
                  Chemical formulaC₇H₇FO₂S
                  Reconstitutiont½ = 1 hour at pH 7.5. Effective concentration: 50 μM.
                  ReversibleN
                  Structure formula ImageStructure formula Image
                  Applications
                  Biological Information
                  Primary Targetserine proteases
                  Purity≥99% by GC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSXT8040000
                  Safety Information
                  R PhraseR: 34

                  Causes burns.
                  S PhraseS: 26-36/37/39-45

                  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                  Wear suitable protective clothing, gloves and eye/face protection.
                  In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Corrosive
                  Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
                  Storage +15°C to +30°C
                  Protect from Moisture Protect from moisture
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  52332

                  References

                  Reference overview
                  Seitz, R., et al. 1993. Int. J. Cancer 53, 514.
                  Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
                  Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
                  Chang, C.T., et al. 1992. Biochem. Int. 28, 707.

                  Citations

                  Title
                • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision19-August-2008 RFH
                  SynonymsBenzylsulfonyl Fluoride, PMSF
                  DescriptionIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.
                  FormWhite to off-white crystalline solid
                  CAS number329-98-6
                  RTECSXT8040000
                  Chemical formulaC₇H₇FO₂S
                  Structure formulaStructure formula
                  Purity≥99% by GC
                  SolubilityEthanol, isopropanol, or methanol
                  Storage +15°C to +30°C
                  Protect from moisture
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
                  Toxicity Corrosive
                  ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
                  Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
                  Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
                  Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
                  Citation
                • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.