516481 | Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem

516481
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₄H₆₃N₅O₉ 26305-03-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      516481-100MG
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          Plastic ampoule 100 mg
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          516481-25MG
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              Plastic ampoule 25 mg
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              516481-5MG
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                  Plastic ampoule 5 mg
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                  Description
                  OverviewA reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cell lines. Also available as a 25 mM solution in DMSO (Cat. No. 508437).
                  Effective concentration: 1.0 µM.
                  Catalogue Number516481
                  Brand Family Calbiochem®
                  SynonymsIva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
                  References
                  ReferencesIsahara, K., et al. 1999. Neuroscience 91, 233.
                  Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
                  Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
                  Carraway, R.E., et al. 1991. Peptides 12, 107.
                  Eid, M., et al. 1981. Biochem. J. 197, 465.
                  Umezawa, H., et al. 1970. J. Antibiot. 23, 259.
                  Product Information
                  CAS number26305-03-3
                  ATP CompetitiveN
                  FormWhite solid
                  Hill FormulaC₃₄H₆₃N₅O₉
                  Chemical formulaC₃₄H₆₃N₅O₉
                  Optical rotationOptical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C).
                  ReversibleY
                  Applications
                  Biological Information
                  Primary Targetcathepsin D
                  Primary Target IC<sub>50</sub>EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines
                  Purity≥98% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSSC6155000
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage +2°C to +8°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  516481

                  References

                  Reference overview
                  Isahara, K., et al. 1999. Neuroscience 91, 233.
                  Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
                  Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
                  Carraway, R.E., et al. 1991. Peptides 12, 107.
                  Eid, M., et al. 1981. Biochem. J. 197, 465.
                  Umezawa, H., et al. 1970. J. Antibiot. 23, 259.
                  Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision11-October-2013 JSW
                  SynonymsIva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
                  DescriptionA reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cells. Effective concentration: 1 µM.
                  FormWhite solid
                  Recommended reaction conditions
                  Activity:
                  Activity is measured by inhibition of pepsin. 1 U corresponds to the amount of inhibitor that reduces the activity of pepsin by 1 U (1 U of enzyme corresponds to the amount of enzyme that results in the increases the absorbance at 280 nm by 0.001 per min at pH 2.0, 37°C.)
                  CAS number26305-03-3
                  RTECSSC6155000
                  Chemical formulaC₃₄H₆₃N₅O₉
                  Purity≥98% by HPLC
                  SolubilityDMSO (1 mg/ml) or Methanol (1 mg/ml)
                  Storage +2°C to +8°C
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
                  Toxicity Standard Handling
                  Merck USA index14, 7147
                  ReferencesIsahara, K., et al. 1999. Neuroscience 91, 233.
                  Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
                  Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
                  Carraway, R.E., et al. 1991. Peptides 12, 107.
                  Eid, M., et al. 1981. Biochem. J. 197, 465.
                  Umezawa, H., et al. 1970. J. Antibiot. 23, 259.