Key Specifications Table
Pricing & Availability
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|516483-1MG||Plastic ampoule||1 mg||
|Overview||A Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells.|
|References||Zaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.|
|Form||White lyophilized solid|
|Formulation||Supplied as a trifluoroacetate salt.|
|Purity||≥97% by HPLC|
|Safety Information according to GHS|
|S Phrase||S: 22-24/25
Do not breathe dust.
Avoid contact with skin and eyes.
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
|Zaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.