516090 | Penciclovir - CAS 39809-25-1 - Calbiochem

516090
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₁₅N₅O₃ 39809-25-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      516090-100MG
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          Plastic ampoule 100 mg
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          Description
          OverviewA carba analog of Ganciclovir (Cat. No. 345700). Active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
          Catalogue Number516090
          Brand Family Calbiochem®
          Synonyms2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
          References
          ReferencesLeary, J.J., et al. 2002.Antimicrob. Agents Chemother. 46, 762.
          Amjad, M., et al. 2001. Microbiol. Immunol. 45, 233.
          Thust, R., et al. 2000. Cancer Gene Ther. 7, 107.
          Thust, R., et al. 1996. Antiviral Res. 31, 105.
          Shaw, T., et al. 1994. Antimicrob. Agents Chemother. 38, 719.
          Harnden, M.R. 1989. J. Med. Chem. 32, 1738.
          Product Information
          CAS number39809-25-1
          FormWhite solid
          Hill FormulaC₁₀H₁₅N₅O₃
          Chemical formulaC₁₀H₁₅N₅O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 46-60-61

          May cause heritable genetic damage.
          May impair fertility.
          May cause harm to the unborn child.
          S PhraseS: 36/37/39-45-53

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          516090

          References

          Reference overview
          Leary, J.J., et al. 2002.Antimicrob. Agents Chemother. 46, 762.
          Amjad, M., et al. 2001. Microbiol. Immunol. 45, 233.
          Thust, R., et al. 2000. Cancer Gene Ther. 7, 107.
          Thust, R., et al. 1996. Antiviral Res. 31, 105.
          Shaw, T., et al. 1994. Antimicrob. Agents Chemother. 38, 719.
          Harnden, M.R. 1989. J. Med. Chem. 32, 1738.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-May-2008 RFH
          Synonyms2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
          DescriptionA synthetic acyclic guanine derivative and a carba analog of Ganciclovir (Cat. No. 345700) that is active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number39809-25-1
          Chemical formulaC₁₀H₁₅N₅O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityAqueous buffer, pH 2.0 (10 mg/ml) or H₂O (1 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index15, 7083
          ReferencesLeary, J.J., et al. 2002.Antimicrob. Agents Chemother. 46, 762.
          Amjad, M., et al. 2001. Microbiol. Immunol. 45, 233.
          Thust, R., et al. 2000. Cancer Gene Ther. 7, 107.
          Thust, R., et al. 1996. Antiviral Res. 31, 105.
          Shaw, T., et al. 1994. Antimicrob. Agents Chemother. 38, 719.
          Harnden, M.R. 1989. J. Med. Chem. 32, 1738.