512732 | Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem

512732
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₂₀O₃ 20554-84-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      512732-50MG
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          Plastic ampoule 50 mg
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          Description
          OverviewA cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
          Catalogue Number512732
          Brand Family Calbiochem®
          References
          ReferencesWong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
          Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
          Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
          Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
          Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
          Product Information
          CAS number20554-84-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₅H₂₀O₃
          Chemical formulaC₁₅H₂₀O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetthe expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSLY4220000
          Safety Information
          R PhraseR: 20/21/22-40-42/43

          Harmful by inhalation, in contact with skin and if swallowed.
          Limited evidence of a carcinogenic effect.
          May cause sensitization by inhalation and skin contact.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          512732

          References

          Reference overview
          Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
          Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
          Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
          Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
          Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-July-2016 JSW
          DescriptionA sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number20554-84-1
          RTECSLY4220000
          Chemical formulaC₁₅H₂₀O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml) or ethanol (20 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          ReferencesWong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
          Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
          Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
          Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
          Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.