505226 Pancuronium Dibromide - CAS 15500-66-0 - Calbiochem

505226
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₅H₆₀N₂O₄•Br₂ 15500-66-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05226.0001
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          Glass bottle 10 mg
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          Description
          OverviewA highly potent competitive antagonist selective for nAChRs (IC50 = 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.
          Catalogue Number505226
          Brand Family Calbiochem®
          Synonyms1,1ʹ-(3α,17β-Dihydroxy-2α,5β-androstan-2-β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide
          References
          ReferencesLowenick et al., 2001. Eur. J. Pharmacol. 413, 31.
          Melnikov, L., et al., 1999. Gen Pharmacol. 33, 313.
          Maestrone, E., et al., 1994. Br. J. Pharmacol. 111, 283.
          Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol. 335, 367.
          Product Information
          CAS number15500-66-0
          FormOff-white solid
          Hill FormulaC₃₅H₆₀N₂O₄•Br₂
          Chemical formulaC₃₅H₆₀N₂O₄•Br₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetnAChR
          Primary Target IC<sub>50</sub>5.5nM
          Purity≥98% by NMR
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25-62-63

          Toxic if swallowed.
          Possible risk of impaired fertility.
          Possible risk of harm to the unborn child.
          S PhraseS: 36/37/39-45-46

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          If swallowed, seek medical advice immediately and show this container or label.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Lowenick et al., 2001. Eur. J. Pharmacol. 413, 31.
          Melnikov, L., et al., 1999. Gen Pharmacol. 33, 313.
          Maestrone, E., et al., 1994. Br. J. Pharmacol. 111, 283.
          Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol. 335, 367.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          Synonyms1,1ʹ-(3α,17β-Dihydroxy-2α,5β-androstan-2-β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide
          DescriptionA highly potent competitive antagonist selective for nAChRs (IC50 = 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.
          FormOff-white solid
          CAS number15500-66-0
          Chemical formulaC₃₅H₆₀N₂O₄•Br₂
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityH₂O (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesLowenick et al., 2001. Eur. J. Pharmacol. 413, 31.
          Melnikov, L., et al., 1999. Gen Pharmacol. 33, 313.
          Maestrone, E., et al., 1994. Br. J. Pharmacol. 111, 283.
          Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol. 335, 367.