506350 | Pam₃Cys-Ser-(Lys)₄, Hydrochloride

506350
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506350-2MG
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          Plastic ampoule 2 mg
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          Description
          OverviewA cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2).
          Catalogue Number506350
          Brand Family Calbiochem®
          Synonyms(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys₄-OH, 3HCl, P₃CSK₄, 3HCl, Pam₃Cys-SK₄, 3HCl, Pam3CSK4, TLR1/TLR2 Agonist I
          References
          ReferencesBarrenschee, M., et al. 2010. PLoS One. 5, e13889.
          Zahringer, U., et al. 2008. Immunology. 213, 205.
          Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
          Muller, M.R., et al. 2001. Immunology 103, 49.
          Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369.
          Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114.
          Offermanns, S., et al. 1992. Biochem. J. 282, 551.
          Seifert, R., et al. 1990. Biochem. J. 267, 795.
          Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.
          Product Information
          CAS number112208-00-1
          FormLyophilized solid
          Hill FormulaC₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
          Chemical formulaC₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
          Applications
          Biological Information
          Purity≥90% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          506350

          References

          Reference overview
          Barrenschee, M., et al. 2010. PLoS One. 5, e13889.
          Zahringer, U., et al. 2008. Immunology. 213, 205.
          Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
          Muller, M.R., et al. 2001. Immunology 103, 49.
          Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369.
          Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114.
          Offermanns, S., et al. 1992. Biochem. J. 282, 551.
          Seifert, R., et al. 1990. Biochem. J. 267, 795.
          Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.

          Citations

          Title
        • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-April-2018 JSW
          Synonyms(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys₄-OH, 3HCl, P₃CSK₄, 3HCl, Pam₃Cys-SK₄, 3HCl, Pam3CSK4, TLR1/TLR2 Agonist I
          DescriptionA cell-permeable, water-soluble, synthetic, cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation, and activates ERK1/2 and MEK1/2. Acts as a selective TLR-2 (Toll-like receptor 2) agonist.
          FormLyophilized solid
          CAS number112208-00-1
          Chemical formulaC₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
          Purity≥90% by HPLC
          SolubilityH₂O (2 mg/ml)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesBarrenschee, M., et al. 2010. PLoS One. 5, e13889.
          Zahringer, U., et al. 2008. Immunology. 213, 205.
          Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
          Muller, M.R., et al. 2001. Immunology 103, 49.
          Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369.
          Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114.
          Offermanns, S., et al. 1992. Biochem. J. 282, 551.
          Seifert, R., et al. 1990. Biochem. J. 267, 795.
          Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.
          Citation
        • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.