534339 PTPσ Inhibitor, ISP - Calbiochem

534339
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₇₇H₃₀₆N₆₆O₅₄S₃

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.34339.0001
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable, TAT conjugated peptide derived from the protein tyrosine phosphatase sigma (PTPsigma) wedge domain that binds to PTPsigma and relieves glial-derived chondroitin sulfate proteoglycan (CSPG)-mediated inhibition. Shown to cross the blood-brain barrier. Does not bind to other CSPG receptors, such as LAR and NgRs. By blocking the PTPsigma-CSPG interaction it abolishes CSPG -mediated inhibition of axonal regrowth and sprouting. Shown to promote adult sensory neuron growth cone (~ 2.5 µM). Restores serotonergic innervations to the spinal cord below the level of injury and promotes progressive functional recovery of both locomotor and urinary systems after spinal cord injury in a rat model (11 µg/day).

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number534339
          Brand Family Calbiochem®
          SynonymsProtein Tyrosine Phosphatase σ Inhibitor, ISP
          References
          ReferencesLang, B. T, et al. 2015. Nature. 518, 404.
          Product Information
          FormWhite solid
          Hill FormulaC₁₇₇H₃₀₆N₆₆O₅₄S₃
          Chemical formulaC₁₇₇H₃₀₆N₆₆O₅₄S₃
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary TargetPTPσ
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceNH2-GRKKRRQRRRCDMAEHMERLKANDSLKLSQEYESI-NH2
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PTPσ Inhibitor, ISP - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Lang, B. T, et al. 2015. Nature. 518, 404.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-December-2016 JSW
          SynonymsProtein Tyrosine Phosphatase σ Inhibitor, ISP
          DescriptionA cell-permeable, TAT conjugated peptide derived from the protein tyrosine phosphatase sigma (PTPsigma) wedge domain that binds to PTPsigma and relieves glial-derived chondroitin sulfate proteoglycan (CSPG)-mediated inhibition. Shown to cross the blood-brain barrier. Does not bind to other CSPG receptors, such as LAR and NgRs. By blocking the PTPsigma-CSPG interaction it abolishes CSPG -mediated inhibition of axonal regrowth and sprouting. Shown to promote adult sensory neuron growth cone (~ 2.5 µM). Restores serotonergic innervations to the spinal cord below the level of injury and promotes progressive functional recovery of both locomotor and urinary systems after spinal cord injury in a rat model (11 µg/day).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₇₇H₃₀₆N₆₆O₅₄S₃
          Peptide SequenceNH2-GRKKRRQRRRCDMAEHMERLKANDSLKLSQEYESI-NH2
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml) or H₂O (100 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLang, B. T, et al. 2015. Nature. 518, 404.