540215 PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem

540215
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₇NO₃ 345630-40-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      540215-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 µM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). Does not effectively inhibit PTPIB (IC50 >30 µM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
          Catalogue Number540215
          Brand Family Calbiochem®
          SynonymsN-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, PTEN Inhibitor V
          References
          ReferencesLi, Y., et al. 2011. Blood 117, 6702.
          Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.
          Product Information
          CAS number345630-40-2
          ATP CompetitiveN
          FormRed-violet solid
          Hill FormulaC₁₉H₁₇NO₃
          Chemical formulaC₁₉H₁₇NO₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCD45 using pNPP as a substrate
          Primary Target IC<sub>50</sub>200 nM or 3.8 µM against CD45 using pNPP or phosphorylated Ick505 peptide as a substrate, respectively
          Purity≥ 97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          540215

          References

          Reference overview
          Li, Y., et al. 2011. Blood 117, 6702.
          Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.

          Citations

          Title
          Kirchberger, S., et al. 2008. Blood 112, 1240. Baba, M., et al. 2007. Journal of Leukocyte Biology 81, 1002.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-July-2012 JSW
          SynonymsN-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, PTEN Inhibitor V
          DescriptionA cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM using pNPP as the substrate, 3.8 µM for CD45 lck, >30 µM for PTP1B lck) that displays anti-proliferative properties. Also reported to potently block T-cell receptor-mediated proliferation (IC50 = 100 nM). Shown to be less cytotoxic (CC50 = 3.5 µM) than other 1,2-naphthalenedione analogs. The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
          FormRed-violet solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number345630-40-2
          Chemical formulaC₁₉H₁₇NO₃
          Structure formulaStructure formula
          Purity≥ 97% by HPLC
          SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          ReferencesLi, Y., et al. 2011. Blood 117, 6702.
          Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.
          CitationKirchberger, S., et al. 2008. Blood 112, 1240. Baba, M., et al. 2007. Journal of Leukocyte Biology 81, 1002.