530050 PRIMA-1 - CAS 5608-24-2 - Calbiochem

530050
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₁₅NO₃ 5608-24-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      530050-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable quinuclidinone analog with antitumor properties. Restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo. Induces apoptosis in breast cancer cells expressing mutant p53.
          Catalogue Number530050
          Brand Family Calbiochem®
          Synonyms2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
          References
          ReferencesBykov, V.J., et al. 2002. Nat. Med. 8, 282.
          Product Information
          CAS number5608-24-2
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₉H₁₅NO₃
          Chemical formulaC₉H₁₅NO₃
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetRestores biochemical and biological function to mutant p53
          Purity≥95% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PRIMA-1 - CAS 5608-24-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          PRIMA-1 - CAS 5608-24-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          530050

          References

          Reference overview
          Bykov, V.J., et al. 2002. Nat. Med. 8, 282.

          Brochure

          Title
          Interactive Pathway Calendar
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-April-2011 RFH
          Synonyms2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
          DescriptionA cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5608-24-2
          Chemical formulaC₉H₁₅NO₃
          Structure formulaStructure formula
          Purity≥95% by NMR
          SolubilityH₂O (2 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesBykov, V.J., et al. 2002. Nat. Med. 8, 282.