539569 PP2C, α-Isoform, His•Tag®, Human, Recombinant, E. coli

539569
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      539569-50UG
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          Plastic ampoule 50 μg
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          Description
          OverviewRecombinant, human PP2Cα fused to a His•Tag® sequence and expressed in E. coli. A Mn2+- or Mg2+-dependent protein serine/threonine phosphatase that is essential for regulating cellular stress response, gene expression and replication in eukaryotes. Recently it has been shown that PP2Cα inhibits cell growth and activates the p53 pathway.
          Catalogue Number539569
          Brand Family Calbiochem®
          SynonymsPPM1A, Protein Phosphatase 2Cα
          References
          ReferencesOfek, P., et al. 2003. J. Biol. Chem. 278, 14299.
          Das, A.K., et al. 1996. EMBO J. 15, 6798.
          Product Information
          Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 nmol of <i>p</i>NPP per min at 37°C, pH 7.4 using 10 mM of substrate.
          FormClear, colorless liquid
          FormulationIn PBS, pH 7.4.
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          Specific Activity≥8,000 units/mg protein
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PP2C, α-Isoform, His•Tag®, Human, Recombinant, E. coli SDS

          Title

          Safety Data Sheet (SDS) 

          PP2C, α-Isoform, His•Tag®, Human, Recombinant, E. coli Certificates of Analysis

          TitleLot Number
          539569

          References

          Reference overview
          Ofek, P., et al. 2003. J. Biol. Chem. 278, 14299.
          Das, A.K., et al. 1996. EMBO J. 15, 6798.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-April-2009 JSW
          SynonymsPPM1A, Protein Phosphatase 2Cα
          DescriptionRecombinant, human PP2Cα fused to a His•Tag® sequence and expressed in E. coli. A Mn2+- or Mg2+-dependent protein serine/threonine phosphatase that is essential for regulating cellular stress response, gene expression and replication in eukaryotes. Recently it has been shown that PP2Cα inhibits cell growth and activates the p53 pathway.
          FormClear, colorless liquid
          FormulationIn PBS, pH 7.4.
          Concentration Label Please refer to vial label for lot-specific concentration
          Purity≥95% by SDS-PAGE
          Specific activity≥8,000 units/mg protein
          Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 nmol of pNPP per min at 37°C, pH 7.4 using 10 mM of substrate.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesOfek, P., et al. 2003. J. Biol. Chem. 278, 14299.
          Das, A.K., et al. 1996. EMBO J. 15, 6798.