527455 | PKR Inhibitor, Negative Control - CAS 852547-30-9 - Calbiochem

527455
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₈Cl₃NO₂ 852547-30-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      527455-10MG
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          Glass bottle 10 mg
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          Description
          OverviewAn oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC50 > 100 µM) or in rescuing PKR-dependent translation block.
          Catalogue Number527455
          Brand Family Calbiochem®
          SynonymsRNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
          References
          ReferencesJammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
          Product Information
          CAS number852547-30-9
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₅H₈Cl₃NO₂
          Chemical formulaC₁₅H₈Cl₃NO₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetA negative control for PKR Inhibitor
          Purity≥95% by HPLC (sum of two isomers)
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          527455

          References

          Reference overview
          Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-September-2007 JSW
          SynonymsRNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
          DescriptionAn oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in the inhibition of RNA-induced PKR autophosphorylation (IC50 > 100 µM). Exhibits no ability to rescue the translational block imposed by human PKR.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number852547-30-9
          Chemical formulaC₁₅H₈Cl₃NO₂
          Structure formulaStructure formula
          Purity≥95% by HPLC (sum of two isomers)
          SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesJammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.