527450 | PKR Inhibitor - CAS 608512-97-6 - Calbiochem

527450
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₈N₄OS 608512-97-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      527450-5MG
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          Glass bottle 5 mg
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          Description
          OverviewAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Inactive control is also available (Cat. No. 527455). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Also available as a 50 mM solution in DMSO (Cat. No. 527451).
          Catalogue Number527450
          Brand Family Calbiochem®
          SynonymsDouble-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
          References
          ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
          Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
          Product Information
          CAS number608512-97-6
          ATP CompetitiveN
          FormOrange to orange brown solid
          Hill FormulaC₁₃H₈N₄OS
          Chemical formulaC₁₃H₈N₄OS
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationPKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block.
          Biological Information
          Primary TargetPKR
          Primary Target IC<sub>50</sub>210 nM inhibiting RNA-induced PKR autophosphorylation and 100 nM in rescuing PKR-dependent translation block
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          527450

          References

          Reference overview
          Zhu, P.J., et al. 2011. Cell 147, 1384.
          Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-April-2018 JSW
          SynonymsDouble-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
          DescriptionAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Inactive control is also available (Cat. No. 527455).
          FormOrange to orange brown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number608512-97-6
          Chemical formulaC₁₃H₈N₄OS
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
          Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.