539654 PKCβ Inhibitor - CAS 257879-35-9 - Calbiochem

539654
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₁N₅O₂ 257879-35-9

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      539654-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewAn anilino-monoindolylmaleimide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI) and displays greater selectivity over PKCα, γ,& ε (IC50 = 331 nM, > 1 µM, and 2.8 µM, respectively).
          Catalogue Number539654
          Brand Family Calbiochem®
          Synonyms3-(1-(3-Imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anilino-1H-pyrrole-2,5-dione
          References
          ReferencesTanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.
          Product Information
          CAS number257879-35-9
          ATP CompetitiveY
          FormOrange solid
          Hill FormulaC₂₄H₂₁N₅O₂
          Chemical formulaC₂₄H₂₁N₅O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKCβII, βI
          Primary Target IC<sub>50</sub>5 nM, 21 nM for human PKCβII and βI
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PKCβ Inhibitor - CAS 257879-35-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          PKCβ Inhibitor - CAS 257879-35-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          539654

          References

          Reference overview
          Tanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2010 RFH
          Synonyms3-(1-(3-Imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anilino-1H-pyrrole-2,5-dione
          DescriptionA potent, cell-permeable, reversible, and ATP-competitive inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI, respectively). Displays greater selectivity for PKCβ compared to PKCα, PKCγ,and PKCε (IC50 = 331 nM, >1 µM, and 2.8 µM, respectively).
          FormOrange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number257879-35-9
          Chemical formulaC₂₄H₂₁N₅O₂
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesTanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.