Key Specifications Table
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|524618-10MG||Glass bottle||10 mg||
|Overview||A cell-permeable DM-PIT-1 (Cat. No. 524619) analog that is more selective and potent than DM-PIT-1 against PH domain-mediated PIP3 (Cat. No. 524615) binding to Akt1 (IC50 = 13.4 and 27.1 µM, respectively) and PDK1 (IC50 = 52.3 and 80.5 µM, respectively), while being much less active than DM-PIT-1 against PIP3 GRP1 PH domain binding (12% vs 84% inhibition with 100 µM respective compound). PIT-7 is also shown to be more effective than DM-PIT-1 in inhibiting human glioblastoma U87MG survival (IC50 = 6.6 vs. 33.9 µM, respectively) and cellular Akt Ser473 phosphorylation in cultures in vitro.|
|Synonyms||Akt Inhibitor XX, PDK1 Inhibitor V, N-(4-Hydroxybiphenyl-3-ylcarbamothioyl)-3,5-dimethylbenzamide, Phosphatidylinositol-3,4,5-triphosphate Antagonist, PITenin-7, PIT-7|
|References||Miao, B., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 20126.|
|Structure formula Image|
|Purity||≥95% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
PIP3 Antagonist, PITenin-7 - Calbiochem SDS
|Miao, B., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 20126.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.