526521 | PIM1 Inhibitor III

526521
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₈H₂₃N₅O₅Ru

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      526521-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewThe racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively).
          Catalogue Number526521
          Brand Family Calbiochem®
          References
          ReferencesBergman, H. and Meggers, E., 2006. Org. Lett. 8, 5465.
          Product Information
          ATP CompetitiveN
          DeclarationSold for research purposes only, pursuant to an agreement with University of Pennsylvania.
          FormPurple solid
          Hill FormulaC₂₈H₂₃N₅O₅Ru
          Chemical formulaC₂₈H₂₃N₅O₅Ru
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPIM1
          Primary Target IC<sub>50</sub>0.5 and 3 nM for the (S)- and (R)-enantiomer, of PIM-1, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          526521

          References

          Reference overview
          Bergman, H. and Meggers, E., 2006. Org. Lett. 8, 5465.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-January-2008 JSW
          DescriptionThe racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively).
          FormPurple solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₈H₂₃N₅O₅Ru
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (6 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesBergman, H. and Meggers, E., 2006. Org. Lett. 8, 5465.