524611 | PIKfyve Inhibitor - CAS 371942-69-7 - Calbiochem

524611
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₂₁N₇O₃ 371942-69-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      524611-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable pyridofuropyrimidine compound that selectively inhibits mammalian type III PtdInsP kinase (IC50 = 33 nM and >5 µM using murine PIKfyve and yeast Fab1, respectively), while exhibiting much reduced activity against p110α (IC50 = 3.3 µM) and little activity against type IIγ PtdInsP kinase even at concentrations as high as 10 µM. Shown to block serum-induced PtdIns(3,5)P2 production in NIH3T3 cells (80% inhibition at 800 nM) and disrupt cellular endosomal transport in a reversible manner.
          Catalogue Number524611
          Brand Family Calbiochem®
          Synonyms6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3ʹ2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide, PtdIns3P 5-KInase Inhibitor, YM201636
          References
          ReferencesJefferies, H.B.J., et al. 2008. EMBO Reports 9, 164.
          Product Information
          CAS number371942-69-7
          FormWhite solid
          Hill FormulaC₂₅H₂₁N₇O₃
          Chemical formulaC₂₅H₂₁N₇O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          524611

          References

          Reference overview
          Jefferies, H.B.J., et al. 2008. EMBO Reports 9, 164.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-January-2009 RFH
          Synonyms6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3ʹ2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide, PtdIns3P 5-KInase Inhibitor, YM201636
          DescriptionA cell-permeable pyridofuropyrimidine compound that selectively inhibits mammalian type III PtdInsP kinase (IC50 = 33 nM and >5 µM using murine PIKfyve and yeast Fab1, respectively), while exhibiting much reduced activity against p110α (IC50 = 3.3 µM) and little activity against type IIγ PtdInsP kinase even at concentrations as high as 10 µM. Shown to block serum-induced PtdIns(3,5)P2 production in NIH3T3 cells (80% inhibition at 800 nM) and disrupt cellular endosomal transport in a reversible manner.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number371942-69-7
          Chemical formulaC₂₅H₂₁N₇O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (1 mg/ml). Enhanced solubility in DMSO can be achieved by the addition of a small drop of TFA.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesJefferies, H.B.J., et al. 2008. EMBO Reports 9, 164.