528110 | PIH - CAS 737-86-0 - Calbiochem

528110
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₄N₄O₃ 737-86-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      528110-50MG
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          Plastic ampoule 50 mg
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          Description
          OverviewA cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity.
          Catalogue Number528110
          Brand Family Calbiochem®
          Synonymspyridoxal isonicotinoyl hydrazone, Iron Chelator III
          References
          ReferencesBuss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
          Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
          Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
          Blaha, K., et al. 1998. Blood 11, 4368.
          Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
          Richardson, D.R.,et al. 1995. Blood 86, 4295.
          Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
          Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
          Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
          Ponka, P., et al. 1979. FEBS Lett. 97, 317.
          Product Information
          CAS number737-86-0
          FormYellow solid
          Hill FormulaC₁₄H₁₄N₄O₃
          Chemical formulaC₁₄H₁₄N₄O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          528110

          References

          Reference overview
          Buss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
          Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
          Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
          Blaha, K., et al. 1998. Blood 11, 4368.
          Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
          Richardson, D.R.,et al. 1995. Blood 86, 4295.
          Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
          Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
          Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
          Ponka, P., et al. 1979. FEBS Lett. 97, 317.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2008 RFH
          Synonymspyridoxal isonicotinoyl hydrazone, Iron Chelator III
          DescriptionA cell-permeable, non-toxic, iron (Fe3+) chelator of the aroyl hydrazone class that exhibits high chelation efficacy. Highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Desferrioxamine (Cat. No. 252750) but has greater access to mitochondrial iron. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Reported to useful in studies of the management of iron overload disease. Inhibits the induction of heme-containing indoleamine 2,3-dioxygenase activity.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number737-86-0
          Chemical formulaC₁₄H₁₄N₄O₃
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (5 mg/ml) or slightly acidic medium
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesBuss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
          Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
          Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
          Blaha, K., et al. 1998. Blood 11, 4368.
          Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
          Richardson, D.R.,et al. 1995. Blood 86, 4295.
          Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
          Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
          Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
          Ponka, P., et al. 1979. FEBS Lett. 97, 317.