500499 | PI 3-K Inhibitor XVIII - Calbiochem

500499
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₁₈H₂₀₂N₃₂O₃₅

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.00499.0001
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          Glass bottle 10 mg
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          Description
          OverviewAn N-myristoylated cell-permeable PI 3-K p110β-derived Gβγ-binding peptide (aa 514-537 in p110β C2-helical linker region) that prevents Gβγ-, but not RTK-, mediated p100β activation both in cell-free assays (1 µM) and in cultures (30 µM in p110β/p85/Akt/Gβγ-transfected HEK 293E cells) without affecting basal p100β activity, p110β-Rab5 interaction, nor Gβγ-dependent activation of adenylyl cyclase or p101-p110γ dimer. The ATP-competitive p110β inhibitior TGX-221 (Cat. No. 528113) can be used in conjunction for studying Gβγ dependency of p110β-mediated cellular functions.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number500499
          Brand Family Calbiochem®
          Synonymsp110β-Gβγ Interaction Inhibitor peptide, Cell-permeable, Myr-N-KAAEIASSDSANVSSRGGKKFLPV-NH₂
          References
          ReferencesDbouk, H.A., et al. 2012. Sci. Signal. 5, ra89.
          Product Information
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₁₈H₂₀₂N₃₂O₃₅
          Chemical formulaC₁₁₈H₂₀₂N₃₂O₃₅
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary TargetGβγ subunit of G-proteins
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceN-Myr-Lys-Ala-Ala-Glu-Ile-Ala-Ser-Ser-Asp-Ser-Ala-Asn-Val-Ser-Ser-Arg-Gly-Gly-Lys-Lys-Phe-Leu-Pro-Val-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Dbouk, H.A., et al. 2012. Sci. Signal. 5, ra89.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-May-2013 JSW
          Synonymsp110β-Gβγ Interaction Inhibitor peptide, Cell-permeable, Myr-N-KAAEIASSDSANVSSRGGKKFLPV-NH₂
          DescriptionA PI 3-K p110β-derived Gβγ-binding peptide (aa 514-537 in p110β C2-helical linker region) is made cell-permeable via N-myristoylation and prevents Gβγ-, but not RTK-, mediated p110β activation both in cell-free immune complex activation assays (complete inhibition by 1 µM peptide) and in cultures (complete inhibition of pAKT T308 by 30 min 30 µM peptide treatment of p110β/p85/Akt/Gβγ-transfected HEK 293E cells) without affecting basal p110β activity, p110β-Rab5 interaction, nor Gαβ-dependent activation of adenylyl cyclase or p101-p110γ dimer. The ATP-competitive p110β inhibitior TGX-221 (Cat. No. 528113) can be used in conjunction for studying Gβγ-dependency of p110β-mediated cellular functions.
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₁₈H₂₀₂N₃₂O₃₅
          Peptide SequenceN-Myr-Lys-Ala-Ala-Glu-Ile-Ala-Ser-Ser-Asp-Ser-Ala-Asn-Val-Ser-Ser-Arg-Gly-Gly-Lys-Lys-Phe-Leu-Pro-Val-NH₂
          Purity≥95% by HPLC
          SolubilityH₂O (25 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesDbouk, H.A., et al. 2012. Sci. Signal. 5, ra89.