528118 | PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem

528118
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₁₉N₇O 371242-69-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      528118-5MG
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          5 mg
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          Description
          OverviewA cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
          Catalogue Number528118
          Brand Family Calbiochem®
          SynonymsPhosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X
          References
          ReferencesBillottet, C., et al. 2009. Cancer Res. 69,1027.
          Ali, K., et al. 2008. J. Immunol. 180, 2538.
          Product Information
          CAS number371242-69-2
          FormWhite powder
          Hill FormulaC₂₂H₁₉N₇O
          Chemical formulaC₂₂H₁₉N₇O
          Structure formula ImageStructure formula Image
          Applications
          ApplicationPI 3-Kδ Inhibitor X, IC87114, CAS 371242-69-2, is a cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110, p110, and p110, respectively).
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          528118

          References

          Reference overview
          Billottet, C., et al. 2009. Cancer Res. 69,1027.
          Ali, K., et al. 2008. J. Immunol. 180, 2538.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-September-2010 RFH
          SynonymsPhosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X
          DescriptionA cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
          FormWhite powder
          CAS number371242-69-2
          Chemical formulaC₂₂H₁₉N₇O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBillottet, C., et al. 2009. Cancer Res. 69,1027.
          Ali, K., et al. 2008. J. Immunol. 180, 2538.