Key Specifications Table
|Empirical Formula||CAS #|
Pricing & Availability
An invalid quantity was specified. The product quantity has been adjusted.
|528114-5MG||Plastic ampoule||5 mg||
|Overview||A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 µM for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 µM). Exhibits similar pharmacokinetics as LY 294002 (Cat. Nos. 440202 & 440204) via oral administration, but is 3-times as potent (ED50 = 27.35 mg/kg, p.o.) in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).|
|Synonyms||5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII|
|References||Ferrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.|
|Structure formula Image|
|Purity||≥98% by HPLC|
|Safety Information according to GHS|
|R Phrase||R: 43
May cause sensitization by skin contact.
|S Phrase||S: 36/37-45
Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
|Ferrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.|