528114 | PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem

528114
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₇NO₄S 6318-41-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      528114-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 µM for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 µM). Exhibits similar pharmacokinetics as LY 294002 (Cat. Nos. 440202 & 440204) via oral administration, but is 3-times as potent (ED50 = 27.35 mg/kg, p.o.) in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).
          Catalogue Number528114
          Brand Family Calbiochem®
          Synonyms5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII
          References
          ReferencesFerrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.
          Product Information
          CAS number6318-41-8
          FormYellow solid
          Hill FormulaC₁₁H₇NO₄S
          Chemical formulaC₁₁H₇NO₄S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 43

          May cause sensitization by skin contact.
          S PhraseS: 36/37-45

          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          528114

          References

          Reference overview
          Ferrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-April-2011 RFH
          Synonyms5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII
          DescriptionA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 µM for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 µM). Exhibits similar pharmacokinetics as LY 294002 (Cat. Nos. 440202 & 440204) via oral administration, but is 3-times as potent (ED50 = 27.35 mg/kg, p.o.) in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number6318-41-8
          Chemical formulaC₁₁H₇NO₄S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (40 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesFerrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.