509664 | PDX1 Inducer, BRD7552 - Calbiochem

509664
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₃H₃₃N₃O₁₅

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.09664.0001
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell permeable, glucose-derived diversity oriented synthesized compound that acts as reversible inducer of PDX1 expression in human PANC-1 cells, primary human islets, and human duct derived cells in a dose-and time-dependent manner with maximal effect observed on day 9 at 5 µM. Its action is dependent on the presence of FOXA2 in cells as FOXA2 knockdown cells treated with this compound do not exhibit any effect on PDX1 expression. Shown to increase H3 acetylation and H3K4me3 and reduce H3K9me3, which is consistent with its transcriptional activation of PDX1. Prolonged treatment of PANC-1 cells (9 days) increases the expression of insulin mRNA and proteins levels. Does not affect cell number and does not influence apoptotic cell death in PANC-1 cells.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number509664
          Brand Family Calbiochem®
          SynonymsPancreatic and Duodenal Homeobox 1 Inducer
          References
          ReferencesYuan, Y., et al. 2013. Chem. Bio. 20, 1513.
          Product Information
          FormWhite powder
          Hill FormulaC₃₃H₃₃N₃O₁₅
          Chemical formulaC₃₃H₃₃N₃O₁₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Yuan, Y., et al. 2013. Chem. Bio. 20, 1513.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2014 JSW
          SynonymsPancreatic and Duodenal Homeobox 1 Inducer
          DescriptionA cell permeable, glucose-derived diversity oriented synthesized compound that acts as reversible inducer of PDX1 expression in human PANC-1 cells, primary human islets, and human duct derived cells in a dose-and time-dependent manner with maximal effect observed on day 9 at 5 µM. Its action is dependent on the presence of FOXA2 in cells as FOXA2 knockdown cells treated with this compound do not exhibit any effect on PDX1 expression. Shown to increase H3 acetylation and H3K4me3 and reduce H3K9me3, which is consistent with its transcriptional activation of PDX1. Prolonged treatment of PANC-1 cells (9 days) increases the expression of insulin mRNA and proteins levels. Does not affect cell number and does not influence apoptotic cell death in PANC-1 cells.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₃H₃₃N₃O₁₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityEthanol (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO.
          Toxicity Standard Handling
          ReferencesYuan, Y., et al. 2013. Chem. Bio. 20, 1513.